I don't actually own any, but they definitely make a difference.
I'm using some small speaker stands for my monitors, and getting them up off the desk makes a massive difference in clarity. Or at least, it did for me. If you put your ear to the desk while listening to something, you can hear how much low frequency energy is resonating through the desk. Once I got the speakers onto stands, there was no sound coming from the desk. I assume that Mo-pads would do this too...